Papers of The 8th Japan Scar Workshop

11. Energy metabolism of keloids and hypertrophic scars

Koichi Ueda1, Norifumi Kurokawa2, Ryoma Touchi3
1:Department of Plastic and Reconstructive Surgery, Osaka Medical College, Osaka, Japan
2:Department of Plastic and Reconstructive Surgery, Takatsuki Hospital, Osaka, Japan
3:Department of Plastic and Reconstructive Surgery, Saiseikai Suita Hospital, Osaka, Japan

Adenosine triphosphate (ATP) and lactate contents of keloids and scars resected from patients were demonstrated by high-performance liquid chromatography. Blood vessels in keloids and hypertrophic scars were investigated morphologically and statistically.
The longer the elapsed time after the trauma, the lower the level of ATP in scar tissue. However, ATP levels in keloids were still high 10 years after the injury. The lactate content of keloids was highest in keloids, as well as red, pink and white scars.
There were fewer capillaries in the keloids than the hypertrophic scars, and the vascular lumen was flattened.
Capillaries in the central region of the keloids tended to be flat, compared with those in the marginal region.
These results indicate that ATP may be produced by anaerobic glycolysis in keloids, and that decreased and narrowed vessels may reduce oxygen perfusion. The inadequate blood supply to keloids causes this to persist.
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