Papers of The 8th Japan Scar Workshop

8. Research of Keloid and Hypertrophic Scars from A Standpoint of Mechanobiology

Rei Ogawa, Satoshi Akaishi, Hiko Hyakusoku
Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan

Keloids and hypertrophic scars are fibroproliferative disorders of the skin caused by abnormal wound healing, and are characterized by chronic inflammation. A recent study on single nucleotide polymorphisms has suggested that keloid generation involves a genetic predisposition. Moreover, recent studies revealed that mechanical forces are important in the generation of such pathological scars. Thus, keloids and hypertrophic scars can be considered as a multifactorial disorder with a genetic disposition that has a tendency to be affected by local factors, such as mechanical force. Both mechanical force reduction and anti-inflammatory treatments play important roles in the current pathological scar-treatment strategy.
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