Papers of The 3rd Japan Scar Workshop

4. A novel therapeutic approaches for wound repair by control release of basic fibroblast growth factor-impregnated gelatin microspheres

Hiroshi Mizuno, MD
Department of Plastic and Reconstructive Surgery
Division of Regenerative Medicine
Nippon Medical School

Management of severely chronic wound due to peripheral arterial disease is a challenging procedure since the incidence of such diseases has increased over time. Recent advancement in the field of regenerative medicine and tissue engineering suggest that it may eventually be possible to repair such a wound.
Previous literatures have suggested that basic fibroblast growth factors-impregnated gelatin microspheres have shown to enhance angiogenesis in the ischemic hind limb and wound healing in chronic skin ulcers in vivo. Based on these facts, we have performed clinical trials for both therapeutic angiogenesis for critical limb ischemia and treating chronic ulcers. So far, therapeutic successes could be achieved in 10 cases of angiogenesis and 3 chronic ulcers.
This paper mainly highlights the role of basic fibroblast growth factor for wound healing, the mechanism of drug delivery system by gelatin microsphere and our clinical results of such a disease.
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