Papers of The 2nd Japan Scar Workshop

9. The expression of MMPs and TIMPs in keloids

Risa Imaizumi1, Naomi Inomata1, Emi Okada1, Yu Maruyama1, Yoshikiyo Akasaka2, Toshiharu Ishii2

1:Department of Plastic and Reconstructive Surgery, Toho University Omori Medical Center, Tokyo, Japan
2:Department of Pathology, School of Medicine, Toho University, Tokyo, Japan

Keloids are characterized by excessive deposition of collagen, which might result from insufficient extracellular matrix degradation. Little is known about the levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in keloids. We determined the expression levels of MMPs and TIMPs in keloids and mature scars. Tissue samples were collected from a total of 85 Japanese patients with keloids (n=60) and mature scars (n=25). Immunohistochemical staining was performed using the standard, indirect immunoperoxidase method to investigate the expression levels of MMP-1, 2, and 9, and TIMP-1, 2, and 3 in keloids and mature scars. The expression levels of MMP-2, TIMP-2, and -3 were significantly higher in keloids than mature scars, but no significant differences in the expression levels of MMP-1, -9, and TIMP-1 were detected.
Copyright(C) 2007 Japan Scar Workshop All rights reserved.